Meglumine
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Price:
Negotiable
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- Total supply:
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Delivery term:
The date of payment from buyers deliver within days
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seat:
Beijing
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Validity to:
Long-term effective
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Last update:
2024-02-04 23:47
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Browse the number:
301
Company Profile
Bowen Casting Co.,LtdBy certification [File Integrity]
Contact:seomaster(Mr.)
Email:
Telephone:
Area:Beijing
Address:Beijing
Website:http://www.metalpart-casting.com/ http://seomaster.sweetherbfood.com/
Product Details
What is N-methylglucamine?
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N-methylglucamine, commonly known as meglumine, is a hexosamine that belongs to the D-glucitol family. This amino sugar is derived from sorbitol and is crystalline in nature. Its main application lies in the preparation of salts of certain acids for the purpose of diagnostic radiopaque. In addition, the antimonate form of meglumine is used as an antiprotozoal agent for treating leishmaniasis.
Being a hexosamine and a secondary amino compound, meglumine has unique properties that make it an effective agent for enhancing the lipid soluble of adenosine cyclic phosphate. This allows it to exert maximum pharmacological effect.
Overall, meglumine chemistry holds significant potential in the field of medicine and biotechnology, and ongoing research is aimed at exploring its diverse applications in different areas.
Methylglucamine comes in the form of white to faintly yellowish-white crystals or powder, and its melting point is around 128-129 ℃. While it can dissolve in water, it dissolves only slightly in ethanol (with only around 1.2g soluble in 100 ml of ethanol at 25 ℃, and 21g soluble at 70 ℃), and it is almost insoluble in chloroform. This substance has a sweet and salty taste which makes it easy to consume.
The contrast medium N-methylglucamine is commonly combined with iodinated organic compounds, including the radiopaque agents diatrizoate meglumine and iodipamide meglumine. This compound is also utilized as an excipient within the pharmaceutical industry, which is derived from sorbitol.
ã€Product name】 Meglumine
ã€CAS No.】 6284-40-8
ã€Synonyms】 Meglumin; Methylglucamine; N-methylglucamine;
ã€Standard】 Medical grade (USP39)
ã€Assay】99.0%~100.5% (dry substance)
ã€AppearanceThe crystals or powder are white to slightly yellowish and do not have any odor. The content should be generated using the information provided in the original text but presented in a highly similar yet unique manner, distinct from the way ChapGPT would generate content.
What is the molecular weight of Meglumin?
Meglumin Molecular Weight: 195.21.
THP-1 cells have been shown to respond well to meglumin, an amino sugar that is derived from sorbitol. Studies have found that the IC50 of meglumin for these cells is approximately 22 μg/mL. This suggests that meglumin may be a useful tool for researchers studying THP-1 cells and the impact of various treatments on these cells. Further research is needed to fully understand the specific effects of meglumin on THP-1 cells and to explore potential applications for this molecule in various areas of research.
Source of Meglumine
Meglumine is a naturally occurring amino sugar that is sourced from sorbitol. This compound can be derived from various biological sources and it is commonly used in the pharmaceutical industry. Its chemical structure is similar to other amino sugars and it has been found to have several therapeutic properties. It is believed that meglumine has anti-inflammatory and analgesic properties, making it an attractive choice for the treatment of various medical conditions. Overall, meglumine is a versatile compound with many potential applications in medicine and research.
Solubility
The solubility of meglumine in PBS, pH 7.2, is approximately 10 mg/ml.
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 Quality standard Â
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Item |
Specifications |
Assay (dry substance) |
99.0%~100.5% |
Identification |
The mixture turns bright yellow and becomes clear |
Absorbance (420nm) |
≤0.030 (20w/v) |
Specific rotation |
-15.7°~ -17.3° |
Melting point |
128.0~132.0℃ |
Clarity and color of the solution |
The solution is clear |
Loss on drying |
≤1.0% |
Residue on ignition |
≤0.1% |
Heavy metals |
≤20ppm |
Reducing substances |
Conform to the requirement |
Residual solvents (CH3OH) |
≤3000ppm |
Appearance |
White to faintly yellowish-white ordorless crystals or powder |
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ã€Packing】 25kgs/drum (standard packing)
ã€Storage】 Tight container, protect from light
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Is meglumine an acid or base?
Meglumine, also known as megluminum or methylglucamine belongs to a class of organic compounds known as hexoses. These are monosaccharides, in which the sugar unit is a six- carbon containing morphology. N-methylglucamine is soluble in water and a very weakly acidic compound based on its pKa.
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What type of compound is meglumine?
Meglumine is a hexosamine and a secondary amino compound. it belongs to a class of organic compounds known as hexoses. These are monosaccharides, which the sugar unit is a six-carbon containing morphology.
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What is meglumine used for?
1) Meglumine is an organic base used as a pH-adjusting agent and solubilizing agent, it is often used with iodinated organic compounds as contrast medium, such as the radiopaque agents diatrizoate meglumine and iodipamide meglumine.
2) Meglumine is useful in ion-exchange resins to chelate boron ions selectively.
3) Widely used in parenteral pharmaceutical formulations and is generally regarded as a nontoxic material at the levels usually employed as an excipient.
4) Employed in the synthesis of surface active agents, pharmaceuticals and dyes.
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 Can Methylglucamine be used as a pharmaceutical excipient?Â
Meglumine is permitted to be used as a pharmaceutical excipient for both oral and parenteral dosage forms by worldwide regulations, the addition of meglumine to pharmaceutical products can be expected to contribute to the stabilization of many drug substances.
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 Production Methods of MethylglucamineÂ
Methylglucamine is prepared by the imination of glucose and monomethylamine in an alcoholic solution, and followed by catalytic hydrogenation.
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Pharmaceutical Applications
Meglumine is an organic base used as a pH-adjusting agent and solubilizing agent, it is often used with iodinated organic compounds as contrast medium, such as the radiopaque agents diatrizoate meglumine and iodipamide meglumine. Primarily in the preparation of soluble salts of iodinated organic acids used as X-ray contrast media.
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 Meglumine SafetyÂ
Meglumine is widely used in parenteral pharmaceutical formulations, generally regarded as a nontoxic material at the levels usually employed as an excipient.
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Storage of Meglumine
The bulk material of Meglumine should be stored in a well-closed container in a cool, dry place. It should not be stored in aluminum containers because it reacts to evolve hydrogen gas. Meglumine discolors if stored in containers made from copper or copper alloys. Stainless steel containers are recommended. Meglumine does not polymerize or dehydrate unless heated above 150°C for prolonged periods.
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